Liquid Chromatography-Mass Spectrometry and Its Applications: A Brief Review (AOICS)- Lupine Publishers
The Liquid Chromatography-Mass Spectrometry (LC-MS) is a powerful
analytical technique with very high sensitivity and specificity. LC-MS
is combination of Liquid Chromatography (LC) and Mass Spectrometry (MS).
With the Liquid Chromatography (LC) the separation of components can be
done and then the sample eluents from LC are transferred into Mass
Spectrometry (MS) where the detection, identification and determination
of masses of components can be done in presence of other components.
LC-MS is used in determination, of pharmaceutical drug substances,
intermediates and its related compounds for quantitative and qualitative
purpose. LC-MS is used most significantly in in-vitro dissolution,
bio-equivalence, bioavailability and metabolite studies. Also LC-MS is
used in basic research, agrochemical, forensic laboratories and food
industries .In this article principle of LC-MS, instrumentation and its
applications are briefly discussed.
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