Novel Stability Indicating RP-HPLC Method for the Simultaneous Estimation of Clindamycin and Adapalene in Pharmaceutical Dosage Forms (AOICS) - Lupine Publishers

 Novel Stability Indicating RP-HPLC Method for the Simultaneous Estimation of Clindamycin and Adapalene in Pharmaceutical Dosage Forms (AOICS) - Lupine Publishers

A simple, accurate, rapid and precise isocratic stability indicating reversed-phase high-performance liquid chromatographic method has been developed and validated for simultaneous determination of Clindamycin and Adapalene in tablets. The chromatographic separation was carried out on C18 BDS Hypersil (150 x 4.6mm, 5μ) with a mixture of mixed phosphate buffer: acetonitrile (55:45%v/v) as a mobile phase at a flow rate of 1.0mL/min. UV detection was performed at 230nm. The retention times were 2.84 and 3.999 min for Clindamycin and Adapalene respectively. Calibration plots were linear (r2=0.999) over the concentration range of 25-150μg/mL for Clindamycin and 2.5-15μg/mL for Adapalene. The method was validated for accuracy, precisio006E, specificity, linearity and sensitivity. The proposed method was successfully used for quantitative analysis of tablets. No interference from any component of pharmaceutical dosage form was observed. Validation studies revealed that method is specific, rapid, reliable, and reproducible. The high recovery and low relative standard deviation confirm the suitability of the method for routine determination of Clindamycin and Adapalene in bulk and tablet dosage form.

https://www.lupinepublishers.com/chemistry-journal/fulltext/novel-stability-indicating-rP-hPLC-method-for-the-simultaneous-estimation-of-clindamycin-and-adapalene-in-pharmaceutical-dosage-forms.ID.000120.php

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Natural Products Isolation: A Challenges and Redressal (AOICS) - Lupine Publishers

Natural Products Isolation: A Challenges and Redressal (AOICS) - Lupine Publishers

Natural Products (NPs) are Chemical compounds directly found from the nature or can say from life. Chemical compounds are the secondary metabolites do not take parts any physiological function of plant and organism, the plant produces these secondary metabolites in stress for defence mechanism against herbivory and other inter-species defences. Various groups of NPs (Chemical compounds) are found in the plant and Animal, but the plant kingdom is very diverse and broad in presence of these chemical compounds (Phytomolecules). Last 20 years almost 50% drugs directly or indirectly derived from NPs for Human welfare, some of them are: Morphine, Penicilline G, Colchin, Pacitaxel, Atorvastatin, Vinblastine and Vincristine etc. NPs have important pharmacological activities act as active component for both traditional and modern medicines and open a rout of drug discovery and development by providing the lead molecules.

https://www.lupinepublishers.com/chemistry-journal/fulltext/natural-products-isolation-a-challenge-and-redressal.ID.000117.php

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Role of Combinatorial, Medicinal & Biological Chemistry in Drug Discovery Development: An Introduction (AOICS) - Lupine Publishers

Role of Combinatorial, Medicinal & Biological Chemistry in Drug Discovery Development: An Introduction (AOICS) - Lupine Publishers 

Combinatorial chemistry, a new approach for greatly reducing the time for the discovery of newer organic motifs, has been developed over the last few years. Combinatorial chemistry (Figure 1) is a technique for creating huge numbers of biologically potent motif and their hybrids, then rapidly screening them for desirable properties 1. Almost pharmaceutical and agrochemical industries uses this strategy because of the potential for immense reducing in time and cost, and several drug candidates presently in clinical trials are products of this methodology. Drug discovery process (Figure 2 & 3) is long, time and money intensive process [1].

https://www.lupinepublishers.com/chemistry-journal/fulltext/role-of-combinatorial-medicinal-biological-chemistry-in-drug-discovery-development-an-introduction.ID.000104.php

http://lupinepublishers.com/chemistry-journal/abstracts/role-of-combinatorial-medicinal-biological-chemistry-in-drug-discovery-development-an-introduction.ID.000104.php

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Heavy Metals Removal from Wastewater by Adsorption on Modified Physically Activated Sewage Sludge (AOICS)- Lupine Publishers

Heavy Metals Removal from Wastewater by Adsorption on Modified Physically Activated Sewage Sludge by M Nageeb Rashed in AOICS in Lupine Publishers

Low cost adsorbent (activated carbon) with a high metal adsorption capacity was prepared from the disposal sewage sludge by physical activation method (Pyrolysis temperatures at 500 °C, 650 °C, 700 °C, 800 °C and 900 °C). The resulting material was evaluated as adsorbents for the removal of Cd, Pb, Cu, and Mn from aqueous solution. The results revealed that sewage sludge activated by pyrolysis at 800 °C [ASS₈₀₀] was the most effective adsorbent for the removal of Cd, Pb, Cu and Mn from polluted water. Batch studies were performed to evaluate the influences of various experimental parameters such as pH, initial metal ion concentration, adsorbent dosage, and contact time and solution temperature. Adsorption of Cd, Pb, Cu and Mn by ASS₈₀₀ increased with increasing pH and adsorbent dosage, while decreasing with the increase of initial metal concentration. From batch adsorption data the optimum conditions for the adsorption of Cd , Pb, Cu and Mn by ASS₈₀₀ were 1gL^-1 adsorbent dosage, 1 hour contact time, 10mgL^-1 initial metal concentration, 25 °C solution temperature; and pH 6 . Adsorption data were well fitted to the Langmuir, and Freundlich isotherms. Thus, simple pyrolysis provide conversion of sewage sludge into inexpensive low-rank adsorbent potentially useful for the removal of heavy metals from polluted water.

https://www.lupinepublishers.com/chemistry-journal/fulltext/heavy-metals-removal-from-wastewater-by-adsorption-on-modified-physically-activated-sewage-sludge.ID.000102.php

http://lupinepublishers.com/chemistry-journal/abstracts/heavy-metals-removal-from-wastewater-by-adsorption-on-modified-physically-activated-sewage-sludge.ID.000102.php