Thursday 29 November 2018

Synthesis and Bioactivity of Novel Tri-Heterocyclic Molecules: {4-[3-({[5-(Substituted)-1,3,4-Oxadiazol-2-Yl] SulfanyljMethyl) Benzoyl] -1 -Piperazinyl} (2-Furyl)Methanones (AOICS) - Lupine Publishers

Synthesis and Bioactivity of Novel Tri-Heterocyclic Molecules: {4-[3-({[5-(Substituted)-1,3,4-Oxadiazol-2-Yl] SulfanyljMethyl) Benzoyl] -1 -Piperazinyl} (2-Furyl)Methanones (AOICS) - Lupine Publishers 

In the presented investigation, some novel tri-heterocyclic benzamides, 8a-g, were synthesized in several steps. First, the electrophilic benzamide, {4-[3-(chloromethyl)benzoyl]-1-piperazinyl}(2-furyl) methanone (3), was synthesized by the reaction of 2- Furoyl-1-piperazine (1) and 3-chloromethylbenzoyl chloride (2). In second series of steps, different carboxylic acids, 4a-g, were refluxed with ethanol and conc. sulfuric acid to form esters, 5a-g. These esters were further refluxed with N2H4.H2O in methanol solution to acquire acid respective hydrazides, 6a-g. These hydrazides were cyclized by refluxing with KOH, ethanol and CS2 into corresponding 1,3,4-oxadiazoles, 7a-g. In the final step, the electrophile, 3, was coupled with synthesized 1,3,4-oxadiazoles, 7a-g, in acetonitrile and potassium carbonate to acquire the targeted tri-heterocyclic molecules, 8a-g. The structural characterization of these novel compounds 8a-g was done by IR, 1H-NMR, 13C-NMR and EI-MS spectral data. These synthesized molecules were subjected to antibacterial and enzyme inhibitory and cytotoxicity evaluation. Among the series, 8b exhibit good enzyme inhibition whereas 8c exhibited good antibacterial and antifungal potential against B. subtilis, E. coli and A. flavus strains, respectively. Most of the molecules possessed moderate cytotoxicity and hence these can be utilized as possible therapeutic agents.


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Monday 26 November 2018

Multi-Component Synthesis of Novel Diazoles: their Characterization and Biological Evaluation (AOICS) - Lupine Publishers

Multi-Component Synthesis of Novel Diazoles: their Characterization and Biological Evaluation (AOICS) - Lupine Publishers

A new series of imidazoles were synthesized by multiple component system through condensation reaction of benzil, substituted aldehydes, substituted anilines and ammonium acetate. Glacial acetic acid was used as solvent. The bonding behavior and structure of the prepared compounds have been deduced from infra red spectroscopy, conduction method, and CHN analysis data. The synthesized imidazoles have been examined for in-vitro antibacterial properties. The results of these studies have shown that all compounds exhibited fair to major antibacterial activity against one or more bacterial strains.


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Friday 23 November 2018

Emerging Trends in Coordination Polymers and Metal-Organic Frameworks: Perspectives, Synthesis, Properties and Applications (AOICS) - Lupine Publishers

Emerging Trends in Coordination Polymers and Metal-Organic Frameworks: Perspectives, Synthesis, Properties and Applications (AOICS) - Lupine Publishers

Coordination polymers including metal-organic frameworks, clathrates and cyanometallates have recently gained significance as an important class of solid state materials. In this critical review, the diversity, classification, synthesis, structure, properties, applications, geometrical and chemical factors that influence their formation have been carefully presented. The synthesis of these new classes of compounds from molecular building blocks and demonstration oftheir high surface area, adsorptive and trapping potentials of molecules, selectivity in separation and uptake of molecules, tunable and modifiable molecular structure, and photoluminescence, magnetic and antimicrobial responses holds the potential for innumerable applications based on these tailored properties.


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Thursday 22 November 2018

Perspectives over the Brazilian Iron-Niobium Production (AOICS)- Lupine publishers

Perspectives over the Brazilian Iron-Niobium Production (AOICS)- Lupine publishers

Niobium is a chemical element, symbol Nb, atomic number 41 (41 protons and 41 electrons) and atomic mass 92.9 u. It is a transition element belonging to the group 5 or 5B of the periodic classification of the elements. The name derives from the Greek goddess Niobe, daughter of Dione and Tantalus - the latter, in turn gave name to another element of the family 5B, tantalum. It is used mainly in alloys of steel for the production of conductive tubes of fluids. Under normal conditions, it is solid. It was discovered in 1801 by the Englishman Charles Hatchett [1].


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Monday 19 November 2018

Role of Combinatorial, Medicinal & Biological Chemistry in Drug Discovery Development: An Introduction (AOICS) - Lupine Publishers

Role of Combinatorial, Medicinal & Biological Chemistry in Drug Discovery Development: An Introduction (AOICS) - Lupine Publishers 

Combinatorial chemistry, a new approach for greatly reducing the time for the discovery of newer organic motifs, has been developed over the last few years. Combinatorial chemistry (Figure 1) is a technique for creating huge numbers of biologically potent motif and their hybrids, then rapidly screening them for desirable properties 1. Almost pharmaceutical and agrochemical industries uses this strategy because of the potential for immense reducing in time and cost, and several drug candidates presently in clinical trials are products of this methodology. Drug discovery process (Figure 2 & 3) is long, time and money intensive process [1].

https://www.lupinepublishers.com/chemistry-journal/fulltext/role-of-combinatorial-medicinal-biological-chemistry-in-drug-discovery-development-an-introduction.ID.000104.php

http://lupinepublishers.com/chemistry-journal/abstracts/role-of-combinatorial-medicinal-biological-chemistry-in-drug-discovery-development-an-introduction.ID.000104.php

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Thursday 15 November 2018

Liquid Chromatography-Mass Spectrometry and Its Applications: A Brief Review (AOICS)- Lupine Publishers

Liquid Chromatography-Mass Spectrometry and Its Applications: A Brief Review (AOICS)- Lupine Publishers

The Liquid Chromatography-Mass Spectrometry (LC-MS) is a powerful analytical technique with very high sensitivity and specificity. LC-MS is combination of Liquid Chromatography (LC) and Mass Spectrometry (MS). With the Liquid Chromatography (LC) the separation of components can be done and then the sample eluents from LC are transferred into Mass Spectrometry (MS) where the detection, identification and determination of masses of components can be done in presence of other components. LC-MS is used in determination, of pharmaceutical drug substances, intermediates and its related compounds for quantitative and qualitative purpose. LC-MS is used most significantly in in-vitro dissolution, bio-equivalence, bioavailability and metabolite studies. Also LC-MS is used in basic research, agrochemical, forensic laboratories and food industries .In this article principle of LC-MS, instrumentation and its applications are briefly discussed.


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Sunday 11 November 2018

Heavy Metals Removal from Wastewater by Adsorption on Modified Physically Activated Sewage Sludge (AOICS)- Lupine Publishers

Heavy Metals Removal from Wastewater by Adsorption on Modified Physically Activated Sewage Sludge by M Nageeb Rashed in AOICS in Lupine Publishers

Low cost adsorbent (activated carbon) with a high metal adsorption capacity was prepared from the disposal sewage sludge by physical activation method (Pyrolysis temperatures at 500 °C, 650 °C, 700 °C, 800 °C and 900 °C). The resulting material was evaluated as adsorbents for the removal of Cd, Pb, Cu, and Mn from aqueous solution. The results revealed that sewage sludge activated by pyrolysis at 800 °C [ASS800] was the most effective adsorbent for the removal of Cd, Pb, Cu and Mn from polluted water. Batch studies were performed to evaluate the influences of various experimental parameters such as pH, initial metal ion concentration, adsorbent dosage, and contact time and solution temperature. Adsorption of Cd, Pb, Cu and Mn by ASS800 increased with increasing pH and adsorbent dosage, while decreasing with the increase of initial metal concentration. From batch adsorption data the optimum conditions for the adsorption of Cd , Pb, Cu and Mn by ASS800 were 1gL-1 adsorbent dosage, 1 hour contact time, 10mgL-1 initial metal concentration, 25 °C solution temperature; and pH 6 . Adsorption data were well fitted to the Langmuir, and Freundlich isotherms. Thus, simple pyrolysis provide conversion of sewage sludge into inexpensive low-rank adsorbent potentially useful for the removal of heavy metals from polluted water.


Friday 9 November 2018

Synthesis and Characterization of Poly (1,4-Benzenedimethylene Phthalate) and the Study of its ability to sorb Pb(II), Cd(II), and Zn(II) ions (AOICS)- Lupine Publishers


Synthesis and Characterization of Poly (1,4-Benzenedimethylene Phthalate) and the Study of its ability to sorb Pb(II), Cd(II), and Zn(II) ions by Fawwaz I Khalili in AOICS in Lupine Publishers

Poly (1,4-benzenedimethylene phthalate) was synthesized by condensation of phthaloyl chloride with 1,4-benzenedimethanol in the presence of pyridine in dry THF at 30 °C . The resulting polymer white powder was characterized by viscosity measurement, FT-IR, 1H and 13C NMR, elemental analysis, thermal (TGA-DSC) methods and scanning electron microscopy. The uptake properties of Pb(II), Zn(II) and Cd(II) metals by the polymer from aqueous solutions were studied by the batch and column techniques as a function of pH, temperature, concentration and contact time.

https://www.lupinepublishers.com/chemistry-journal/fulltext/synthesis-and-characterization-of-poly-1-4-benzenedimethylene-phthalate-and-the-study-of-its-ability-to-sorb-pb(II)-cd(II)-and-Zn(II)-ions.ID.000101.php

http://lupinepublishers.com/chemistry-journal/abstracts/synthesis-and-characterization-of-poly-1-4-benzenedimethylene-phthalate-and-the-study-of-its-ability-to-sorb-pb(II)-cd(II)-and-Zn(II)-ions.ID.000101.php

Archives Of Organic And Inorganic Chemical Sciences (AOICS) (ISSN: 2637-4609) - Lupine Publishers



An archive of organic and inorganic chemical sciences is a broad-based journal, which consists of specialized articles in various areas like formation of several organic and inorganic compounds and their specific classes such as aldehydes and ketones. The aim of the journal is to provide a platform for the researchers and academicians throughout the world to speedily publish, share and discuss various new findings and developments in the areas of chemical sciences. This journal is related to: stereochemistry, biochemistry, organometallic chemistry, catalysis, supramolecular chemistry, materials science, organic synthesis, natural products, heterocyclic chemistry, industrial inorganic chemistry, NMR spectroscopy, electrochemistry, organometallic compounds, etc.

Prediction of Physico-Chemical Properties for Polycyclic Aromatic Hydrocarbons Based on Electronic Characteristics of Molecules

Abstract QSPR models have been developed to predict of polycyclic aromatic hydrocarbons (PAHs) based on quantum chemical and integr...