Chemical Science Open Access Journals- Lupine Publishers

Synthesis and Characterization of Novel Series of 1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazole Derivatives of Anilinoacetic Acids as Promising Antioxidant Agents by Balakrishna Kalluraya in Archives of Organic and Inorganic Chemical Sciences  in Lupine Publishers

The preparation of a novel series of 6-arylaminomethyl-3-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles (5) by the cyclocondensation of 5-substituted-4-amino-3-mercapto-1,2,4-triazoles (2) with appropriately substituted anilinoacetic acids (4) employing phosphorous oxychloride is reported. The newly synthesized compounds (5) were screened for their antioxidant activity by DPPH radical scavenging assay and their structures were elucidated on the basis of their ¹H-NMR, IR, Mass spectral and elemental analysis. Some of the tested compounds showed good DPPH radical scavenger activities comparable to that of standard BHA.

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