Synthesis, 1H-NMR, GC-MS Characterization, and in Vitro Bactericidal Studies of an Aqueous Soluble Vanadium (IV) Complex with Dipicolinic Acid and Methylsalysilateligands by Tulio Chavez Gil in Archives of Organic and Inorganic Chemical Sciences in Lupine Publishers
The fast emerging of superbugs’ resistance against common commercial antibiotics has been timely challenges and temporarily assuaging outbreak concerns in modern medicine. But coincidentally, there has been a significant retraction on new drugs design as effective antimicrobial medicines by the major pharmaceutical companies with the coinciding escalation in global nosocomial infection. Originally, antibiotics were described as “produced by microorganisms and which possess the property of inhibiting the growth and even of destroying other microorganisms" [1]. Now a day's most commercially antibiotics however, are obtained from other sources than microbiological processes with many clinically “antibiotic drugs” being either synthetic or semi-synthetic ones. Some of these new synthetic antibiotics are characterized by the presence of specific metals to function properly as an integral part of the structure and function as defined in the medicine SAR's interpretation [2]. Therefore, the removal of essential metal ions from these medicines might results in the deactivation and/or change in the structure of the mas observed on bacitracin, bleomycin (BLM), streptonigrin (SN), and albomycin [3]. In addition, the presence of metalsin some antibiotics engender bacteria with biochemical consequences but do not significantly affect the structure of the drug, such as occur in metallated tetracycline's (TCs), aureolic acids, and quinolones. Similar to the case of "metallo proteins,” these families of antibiotics are thus dubbed "metallo antibiotics” and are under scrutiny in our research with the aim of improve the reduced scope of non- β -lactamase bactericidal/ bacterio static agents.
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