Synthesis, 1H-NMR, GC-MS Characterization, and in Vitro Bactericidal Studies of an Aqueous Soluble Vanadium (IV) Complex with Dipicolinic Acid and Methylsalysilateligands by Tulio Chavez Gil in
Archives of Organic and Inorganic Chemical Sciences in
Lupine Publishers
The fast emerging of superbugs’ resistance against common commercial
antibiotics has been timely challenges and temporarily assuaging
outbreak concerns in modern medicine. But coincidentally, there has been
a significant retraction on new drugs design as effective antimicrobial
medicines by the major pharmaceutical companies with the coinciding
escalation in global nosocomial infection. Originally, antibiotics were
described as “produced by microorganisms and which possess the property
of inhibiting the growth and even of destroying other microorganisms"
[1]. Now a day's most commercially antibiotics however, are obtained
from other sources than microbiological processes with many clinically
“antibiotic drugs” being either synthetic or semi-synthetic ones. Some
of these new synthetic antibiotics are characterized by the presence of
specific metals to function properly as an integral part of the
structure and function as defined in the medicine SAR's interpretation
[2]. Therefore, the removal of essential metal ions from these medicines
might results in the deactivation and/or change in the structure of the
mas observed on bacitracin, bleomycin (BLM), streptonigrin (SN), and
albomycin [3]. In addition, the presence of metalsin some antibiotics
engender bacteria with biochemical consequences but do not significantly
affect the structure of the drug, such as occur in metallated
tetracycline's (TCs), aureolic acids, and quinolones. Similar to the
case of "metallo proteins,” these families of antibiotics are thus
dubbed "metallo antibiotics” and are under scrutiny in our research with
the aim of improve the reduced scope of non- β -lactamase bactericidal/
bacterio static agents.
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